Blueberries grow best in acidic soil and are subject to few pests and diseases. Because they are not self-fruitful, two compatible varieties should be planted to ensure good fruit set. If maintained with mulching, it may endure temperatures as low as 10 degrees Fahrenheit. The plants mature to heights from 3 to 6 feet, with a width of up to 4 feet. The plant has few insect or disease problems, however birds and squirrels consume its fruit.